Journal: Journal of Antimicrobial Chemotherapy
Article Title: Enhanced antimycobacterial efficacy of simulated inhaled clofazimine versus oral clofazimine in combination with azithromycin and ethambutol in a hollow-fiber system
doi: 10.1093/jac/dkaf402
Figure Lengend Snippet: Hollow fiber pharmacodynamic effects (mean and error bars) of orally administered clofazimine and inhaled clofazimine (with a backbone of azithromycin and ethambutol) and unexposed growth controls. (I) represents the intracellular fraction. (E) represents the extracellular fraction. Lines connect log 10 cfu/mL measurements. The dashed lines represent the density of M. avium subpopulations within the hollow-fibre system that exhibit tolerance to azithromycin at concentrations 8× the initial MIC.
Article Snippet: Briefly, cellulosic hollow-fiber cartridges (C8008, FiberCell Systems, New Market, MD, USA) were first rinsed with Milli-Q water for 24 hours, followed by washing with RPMI 1640 supplemented with 2% FBS.
Techniques: